Playing early, Wie recorded 14 pars, three birdies and a lone bogey on the Donald Ross layout, which measured 6,291 yards on Friday. She hit 10 of 14 fairways, 14 of 18 greens and had 29 putts.
"I think this is the third stage of her professional career," said Golf Channel analyst Brandel Chamblee.
"I think what we are seeing in Michelle Wie is that for the first time since she was a child, she can devote all of her energy to her professional career. She has made improvements in every aspect in that regard."
"What a great way to finish off her round," Golf Channel's Karen Stupples said about Wie, who birdied 8 and 9, her final two holes of the second round.
"Her stroke looks really good. I just hope she can continue that and keep it going. As the pressure increases, that is going to be the hardest thing for her."
First-round leader Stacy Lewis is currently 2 over through eight holes of her second round and trails Wie by three strokes.
Source: Michelle Wie Leads at Pinehurst